pigment epithelium-derived factor

neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells; has been shown to be the most potent inhibitor of angiogenesis in the mammalian eye; from cultured pigment epithelial cells of the fetal retina; extracellular neurotrophic protein belonging to the serpin family; amino acid sequence given in first source; also found in fibroblast-like cells; RefSeq NM_002615 (human), NM_011340 (mouse), NM_177927 (rat); do not confuse with EPC1 protein, an enhancer of polycomb homolog 1 protein

Also Known As:

Dmrs91 protein, rat; PEDF protein, human; Pedf protein, mouse; Pedfl protein, mouse; SERPIN-F1; SERPINF1 protein, human; Sdf3 protein, mouse; Serpinf1 protein, mouse; Serpinf1 protein, rat; alpha-2 antiplasmin protein, mouse; alpha-2 antiplasmin protein, rat; early PDL protein; early population doubling level cDNA-1 protein; early population doubling level protein; pigment epithelium derived factor protein, mouse; pigment epithelium-derived factor protein, rat; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 protein, human; serine (or cysteine) proteinase inhibitor, clade F, member 1 protein, mouse; serine (or cysteine) proteinase inhibitor, clade F, member 1 protein, rat

Pharmalogical Action Categories:

D011480 - Protease Inhibitors

Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Intercellular Signaling Peptides and Proteins: 30151
    - Nerve Growth Factors: 5170
      - pigment epithelium-derived factor: 679
  - Serpins: 928
    - pigment epithelium-derived factor: 679
  - Nerve Tissue Proteins: 3
    - Nerve Growth Factors: 5170
      - pigment epithelium-derived factor: 679
  - Eye Proteins: 2
    - pigment epithelium-derived factor: 679
- Peptides: 84029
  - Intercellular Signaling Peptides and Proteins: 30151
    - Nerve Growth Factors: 5170
      - pigment epithelium-derived factor: 679
  - Serpins: 928
    - pigment epithelium-derived factor: 679
Biological Factors: 2560
- Intercellular Signaling Peptides and Proteins: 30151
  - Nerve Growth Factors: 5170
    - pigment epithelium-derived factor: 679
Chemical Actions and Uses
- Pharmacologic Actions: 164
  - Molecular Mechanisms of Pharmacological Action: 26
    - Enzyme Inhibitors: 1680
      - Protease Inhibitors: 6351
        Serine Proteinase Inhibitors: 1399
        Serpins: 928
        pigment epithelium-derived factor: 679

Takafumi Tomiyasu Selected Research

Takafumi Tomiyasu Research Topics

Disease

Drug/Important Bio-Agent (IBA)